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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Selective factor 1 ： ウィキペディア英語版 Selective factor 1 Selective factor 1 (also known as SL1) is a transcription factor that binds to the promoter of rDNA genes that were previously silent and recruits a preinitiation complex to which RNA polymerase I will bind to begin the transcription of ribosomal RNA (rRNA). ==Discovery of SL I== SL1 was discovered by Robert Tjian and his colleagues in 1985 when they separated a HeLa cell extract into two functional fractions. One factor has RNA polymerase I activity, but no ability to initiate accurate transcription of a human rRNA template. This transcription factor, SL1, showed species specificity That is, it could distinguish between the human and mouse rRNA promoter, and added increasing amount of human template at the expense of the mice template. Tijian and coworkers went on to show that by footprinting a partially purified polymerase 1 preparation could bind to the human rRNA promoter. In particular it causes a footprint over a region of the UCE called ''A site''. This binding is not due to polymerase I itself but to a transcription factor called upstream binding factor, UBF. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Selective factor 1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.